hFGFR2b/MC-38
CBPG0206
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| I. Background | |
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FGFR2B 是成纤维细胞生长因子受体 2（FGFR2）的剪接变体之一，属于受体酪氨酸激酶（RTK）家族，由胞外配体结合域（含三个免疫球蛋白样结构域）、跨膜区及胞内酪氨酸激酶域组成。其特异性由外显子 IIIb 的选择性剪接决定，主要在上皮细胞表达，与间质细胞来源的 FGFR2C（IIIc 剪接变体）形成旁分泌信号轴，调控上皮-间质相互作用。
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II. Introduction
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Host Cell:
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MC-38
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Expressed gene:
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hFGFR2b
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Stability:
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32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
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Freeze Medium:
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90% FBS+10% DMSO
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Culture Medium:
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DMEM+10%FBS+2μg/ml Puromycin
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Mycoplasma Testing:
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Negative
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Storage:
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Liquid nitrogen
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III. Description of Host Cell Line
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Organism:
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Mus musculus, mouse
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Tissue:
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Colon
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Morphology:
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Epitheloid cell
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Growth Properties:
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Adherent
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IV. Representative Data
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 6weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hFGFR2b/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hFGFR2b/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
